Magnolin Protects against Contrast-Induced Nephropathy in Rats via Antioxidation and Antiapoptosis

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Magnolin Protects against Contrast-Induced Nephropathy in Rats via Antioxidation and Antiapoptosis

BACKGROUND Magnolin is the major active ingredient of the herb Magnolia fargesii which has anti-inflammatory and antioxidative effects. Oxidative stress and apoptosis are involved in the pathogenesis of contrast-induced nephropathy (CIN). We hypothesize that Magnolin could protect against CIN through antioxidative and antiapoptotic properties. METHODS To test whether Magnolin could attenuate ...

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Renalase Protects against Contrast-Induced Nephropathy in Sprague-Dawley Rats

BACKGROUND Contrast-induced nephropathy (CIN) is the third leading cause of hospital-acquired acute renal failure. Oxidative stress, apoptosis and inflammation play crucial roles in CIN. Renalase is a newly discovered monoamine oxidase from the kidney. We hypothesize that renalase could protect against CIN through anti-oxidation, anti-inflammation and anti-apoptosis pathways. METHODS We teste...

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Limb ischemic preconditioning protects against contrast-induced nephropathy via renalase

Clinical trials shows that remote ischemic preconditioning (IPC) can protect against contrast induced nephropathy (CIN) in risky patients, however, the exact mechanism is unclear. In this study, we explored whether renalase, an amine oxidase that has been previously shown to mediate reno-protection by local IPC, would also mediate the same effect elicited by remote IPC in animal model. Limb IPC...

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Limb ischemia protects against contrast-induced nephropathy.

Contrast-induced acute kidney injury (CI-AKI), or nephropathy (CIN), is frequently diagnosed in the setting of coronary angiography. The incidence varies in the literature partly related to the differences in diagnostic criteria used for CIN. In a recently published article in Circulation, Maioli et al1 used a definition of an increase of 0.5 mg/dL over baseline serum creatinine within 3 days o...

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ژورنال

عنوان ژورنال: Oxidative Medicine and Cellular Longevity

سال: 2014

ISSN: 1942-0900,1942-0994

DOI: 10.1155/2014/203458